The role of NR and NAD+ in aging
Explore the Nullure formulas customers choose most often, with science-led ingredients, clean...
Every Nullure product uses ingredients sourced from trusted partners, is third-party tested in Germany for purity and carefully manufactured in small batches in Spain funder strict EU GMP standards.
Reference link
1. Yoshino J, Baur J, Imai S. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018 Mar; 27(3): 513-528
2. Fang E, Lautrup S, Hou Y, Demarest T, Croteau D, Mattson M, et al. NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends Mol Med. 2017 Oct; 23(10): 899-916.
3. Mehmel M, Jovanovic N, Spitz U. Nicotinamide Riboside—The Current State of Research and Therapeutic Uses. Nutrients .2020 Jun; 12(6): 1616.
4. Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin G. Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue. Plos One [Internet]. 2012 Jul [cited 2023 Aug 24]; 7(7): e42357.
5. Aman Y, Qiu Y, Tao J, Fang E. Therapeutic potential of boosting NAD+ in aging and age-related diseases. Transl Med Aging. 2018 Jan; 2: 30-37.
6. Trammell S, Schmidt M, Weidemann B, Redpath P, Jaksch F, Dellinger R, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun [Internet]. 2016 Oct [cited 2023 Aug 24]; 7: 12948.
7. Airhart S, Shireman L, Risler L, Anderson G, Gowda G, Raftery D, et al. An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. Plos One [Internet]. 2017 Dec [cited 2023 Aug 24]; 12(12): e0186459.
8. Dellinger R, Santos S, Morris M, Evans M, Almanina D, Guarente L, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017 Nov; 3: 17.
9. Martens C, Denman B, Mazzo M, Armstrong M, Reisdorph N, McQueen M, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018 Mar; 9(1): 1286.
10. Elhassan Y, Kluckova K, Fletcher R, Schmidt M, Garten A, Doig C, et al. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Rep. 2019 Aug; 28(7): 1717-1728
11. Lapatto H, Kuusela M, Heikkinen A, Muniandy M, van der Kolk M, Gopalakrishnan S. Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study. Sci Adv [Internet]. 2023 Jan [cited 2023 Aug 24]; 9(2): eadd5163. 10.1126/sciadv.add5163
12. Remie C, Roumans K, Moonen M, Connell N, Havekes B, Mevenkamp J, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020 Aug; 112(2): 413-426.
13. Dolopikou C, Kourtzidis I, Margaritelis N, Vrabas I, Koidou I, Kyparos A, et al. Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study. Eur J Nutr. 2020 Mar; 59(2); 505-515.
14. Heilbronn L. Clinical Trials Corner. Nutr Healthy Aging. 2017 Mar; 4(2): 193-194.
15. Brakedal B, Dolle C, Riemer F, Ma Y, Nido G, Skeie G. The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease. Cell Metab. 2022 Mar; 3483): 396-407.
Every formula is built on ingredients backed by human clinical studies, dosed at effective levels, and chosen for bioavailability — how well your body absorbs and uses them. Each ingredient is rigorously vetted and sourced from trusted partners who standardize and batch-test for potency, ensuring quality and real, consistent results.
The NULLURE Safety Standard
The formulas our customers come back to, month after month. Developed in-house by nutrition experts, dosed for real results, and tested beyond industry standards. Rooted in research, confirmed by the people who take them every day.
We write about health and wellness the way we formulate — starting from the research. Every article is written by qualified experts in nutrition, health, and human performance and based on peer-reviewed science. If you're curious about nutrition, supplements, and how your body works, the Nullure Journal might be just the thing for you.
Our community is our biggest motivation. Every day, real people share how Nullure fits into their lives — their routines, their goals, their results. Every person who chooses us is a reminder of why we do this and we are grateful for every story they share. Follow us — we'd love to see yours.
Our ambassadors in the health and science space share the same standards we do — evidence-based, rigorous, and uncompromising on quality. They choose Nullure because they know exactly what goes into every capsule — and why.