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More Focus & Cortisol Balance

PS-100

PS-100

Cortisol balance Mental clarity Better Sleep Cognitive support
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Formulated by experts, built on scientific research, and made without additives.

Every Nullure product uses ingredients sourced from trusted partners, is third-party tested in Germany for purity and carefully manufactured in small batches in Spain funder strict EU GMP standards.

PS-100
+ Supports recall
+ Supports sustained attention
+ Helps regulate the HPA-axis, so cortisol doesn't spike as hard under pressure

Supplement Facts per daily serving (3 capsules):

Phosphatidylserine_________________ 600mg
of which Phosphatidylserine________ 300mg

Take 3 capsules daily, preferably with meals.

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The Nullure Journal

We write about health and wellness the way we formulate — starting from the research. Every article is written by qualified experts in nutrition, health, and human performance and based on peer-reviewed science. If you're curious about nutrition, supplements, and how your body works, the Nullure Journal might be just the thing for you.

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  • Understanding the Brain-Body Connection: Key Insights on Neuroinflammation, Gut Health | Nullure
    Zeynep Özdemir

    Understanding the Brain-Body Connection: Key Insights on Neuroinflammation, Gut Health | Nullure

    There’s a strong connection between neuroinflammation and chronic diseases. Persistent brain inflammation contributes to neurodegenerative diseases like Parkinson’s and Alzheimer’s, as well as mental health challenges such as depression and anxiety. Conditions like diabetes and heart disease, which cause systemic inflammation, can also trigger brain inflammation, creating a harmful cycle. By reducing inflammation, we can support brain health and potentially prevent or slow chronic disease progression. In this article, we delve into key aspects of these interconnected systems. Explore what neuroinflammation is, its link to chronic disease, and practical ways to manage it. Additionally, we’ll examine the gut-brain axis, highlighting how gut health affects mental wellness and discussing dietary and supplementary support for improved outcomes. Why Neuroinflammation Matters and How to Manage It What is Neuroinflammation? Neuroinflammation refers to the immune system’s response within the central nervous system (CNS), particularly the brain and spinal cord. While inflammation is a natural mechanism to combat infections or injuries, chronic inflammation in the brain can lead to significant issues. It is driven by overactivation of microglia, the brain’s resident immune cells, which release inflammatory molecules such as cytokines and chemokines. (1, 2) This prolonged inflammatory state disrupts the balance of brain health, impairing neuronal communication and damaging brain tissue. Over time, it can lead to cognitive health problems, including memory loss and a decline in mental sharpness. Understanding what neuroinflammation is and why it matters is crucial to mitigating its impact. (2) Link Between Neuroinflammation and Chronic Disease There’s a strong connection between neuroinflammation and chronic diseases. Research indicates that persistent brain inflammation is a contributing factor to neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases. It also exacerbates cognitive decline, depression, and anxiety, showcasing its far-reaching effects on mental and physical health. (3, 4, 5) Chronic diseases, including diabetes, cardiovascular conditions, and autoimmune disorders, often involve systemic inflammation, which can spill over into the CNS. This bidirectional relationship highlights the importance of managing inflammation at both the systemic and neuronal levels. (3, 4) Triggers of Neuroinflammation Neuroinflammation can be triggered by various factors, many of which are linked to modern lifestyles. Understanding these causes and triggers of brain inflammation is critical for prevention and management. Chronic Stress: Persistent stress overstimulates the hypothalamic-pituitary-adrenal (HPA) axis, leading to elevated cortisol levels. Over time, this can activate microglia and contribute to brain inflammation. (6, 7) Poor Diet: Diets high in refined sugars, trans fats, and processed foods promote systemic inflammation, which can cross into the brain. These foods that cause neuroinflammation often disrupt the gut microbiome, worsening the gut-brain connection. (8, 9) Infections: Viral, bacterial, or fungal infections can spark an immune response in the central nervous system, leading to prolonged inflammation if not resolved. (10) Environmental Toxins: Exposure to pollutants, heavy metals, and pesticides can induce oxidative stress and damage neurons, further fueling neuroinflammation symptoms. (11, 12) Sleep Disorders: Poor sleep quality or chronic insomnia disrupts the brain’s natural detoxification process, allowing inflammatory compounds to accumulate. (13) Chronic Diseases: Conditions like obesity, diabetes, and cardiovascular disease often involve systemic inflammation that can exacerbate brain inflammation. (14, 15) Practical Tips to Manage Neuroinflammation Reducing neuroinflammation naturally involves lifestyle adjustments and targeted strategies. Here’s how we can take control: Adopt an Anti-Inflammatory Diet: Focus on a diet for brain health rich in whole foods, such as leafy greens, berries, fatty fish, and nuts. These provide antioxidants and omega-3 fatty acids that combat inflammation. Avoid highly processed foods and excessive sugar. (16, 17) Incorporate Anti-Inflammatory Supplements: Supplements like curcumin, omega-3 fatty acids, and saffron are known to reduce inflammation. Adding top supplements for reducing brain inflammation can support long-term cognitive health. (18, 19) Prioritize Gut Health: Maintaining a balanced gut microbiome with probiotics for mental health and prebiotics can help reduce systemic and brain inflammation. A healthy gut fortifies the gut-brain connection, preventing inflammation from spreading to the brain. (20) Manage Stress: Practicing mindfulness, meditation, or yoga can regulate the HPA axis and reduce cortisol levels. A calm mind supports better brain health and minimizes inflammation. (21) Improve Sleep Hygiene: Ensure 7–9 hours of quality sleep each night. Deep sleep helps the brain clear waste products and inflammatory compounds. (22, 23) Exercise Regularly: Moderate physical activity reduces systemic inflammation and improves blood flow to the brain, supporting both brain health and the vagus nerve for improved communication between the gut and brain. (24) Limit Exposure to Toxins: Minimize contact with environmental pollutants and opt for organic foods when possible to reduce toxin-induced brain inflammation. (25) The Gut-Brain Connection: A Deeper Dive The gut-brain connection is a two-way communication network between the central nervous system and the gut, often referred to as the "second brain." This connection is vital for regulating mood, cognition, and overall mental health. Let’s explore the gut-brain axis and its profound impact on our well-being. (26) Understanding the Gut-Brain Axis The gut-brain axis is the bidirectional link between the gut and the brain, mediated by the vagus nerve, hormones, and the immune system. The gut houses trillions of microorganisms collectively known as the gut microbiome, which play a pivotal role in brain and cognitive health. Vagus Nerve Communication: This nerve acts as a highway, transmitting signals between the gut and the brain. For example, inflammation in the gut can send stress signals to the brain, affecting mood and cognition. (27, 28) Gut Microbiome’s Role: A balanced gut microbiome supports the production of neurotransmitters like serotonin and dopamine, which are crucial for emotional and mental stability. (29) Leaky Gut and Inflammation: A compromised gut lining, often called "leaky gut," allows harmful substances to enter the bloodstream. This can trigger systemic inflammation, which ultimately affects brain health. (30, 31) Understanding the gut-brain axis and its role in health is key to improving mental and physical resilience. How Gut Health Affects Mental Health A healthy gut is essential for maintaining a balanced mind. Here’s how:Supports Serotonin Production:  About 90-95% of serotonin, the "feel-good" hormone, is produced in the gut. An unhealthy gut can disrupt its production, contributing to anxiety and depression. (32, 33, 34, 35) Reduces Systemic Inflammation: A healthy gut limits systemic inflammation, protecting the brain from inflammatory damage that can impair cognitive health and emotional regulation. (36, 37) Regulates Stress Responses: A balanced gut microbiome helps regulate the HPA axis, minimizing stress responses and supporting the vagus nerve for better mental health. (33) Protects Against Depression: Studies have shown a direct link between gut microbiome and depression, highlighting the need to prioritize gut health for mental wellness. (32, 38) Top Dietary and Supplementary Support for Gut Health To strengthen the gut-brain connection and promote mental well-being, consider these dietary and supplementary approaches: Probiotics: Foods like yogurt, kefir, and fermented vegetables introduce beneficial bacteria to the gut. Adding probiotics for mental health can improve mood and reduce anxiety. (39, 40) Prebiotics: Found in a variety of fiber-rich foods, such as fruits, vegetables, and legumes, prebiotics serve as nourishment for beneficial gut bacteria, fostering a healthy and robust microbiome. The more variety you get, the better for supporting your microbiome diversity. (41, 42) Anti-Inflammatory Foods: Include foods rich in omega-3 fatty acids (e.g., salmon, walnuts) and polyphenols (e.g., berries, green tea) to reduce inflammation and protect both gut and brain health. (17, 43) Gut Health Supplements: Supplements such as L-glutamine, zinc, and digestive enzymes repair the gut lining and support a healthy microbiome, enhancing the gut-brain axis. (44, 45) Targeted Herbal Supplements: Certain herbs and natural extracts can play a significant role in supporting the gut-brain connection. For example ashwagandha helps regulate stress by balancing cortisol levels, reducing inflammation, and improving gut resilience to stress. Rhodiola Rosea enhances serotonin production, reduces fatigue, and supports mental resilience, positively influencing the gut-brain axis. (45, 47, 48, 49, 50, 51) Hydration: Staying hydrated aids digestion and supports a healthy gut lining. (52)Limit Trigger Foods: Avoid foods high in sugar, trans fats, and artificial additives, which disrupt the microbiome and contribute to leaky gut. (53, 54) By adopting these strategies, we can nurture the gut-brain connection and foster better mental health, resilience, and cognitive performance. Nullure's Suggestion for Supporting Brain and Gut Health:  To further enhance your brain and gut health, we recommend the following Nullure products: Memory-Focus-Nootropic: Our Memory & Focus supplement is formulated to boost cognitive performance through a powerful blend of ingredients like Cognizin, Ginseng, and B Vitamins. It enhances memory, focus, and attention while supporting overall brain health by maintaining healthy levels of protective neurotransmitters and ensuring a balanced neuronal growth and neuroprotection. This supplement is essential for anyone looking to fuel brain energy, support neurotransmitter balance, and promote healthy aging. Ashwagandha KSM-66: Ashwagandha KSM-66 is a premier adaptogen that enhances mental and physical wellness by modulating stress responses and supporting overall homeostasis. It significantly reduces stress and anxiety, improves sleep quality, and boosts memory and cognition. Additionally, it enhances energy levels and physical performance, making it an excellent choice for those looking to increase endurance and manage daily stressors effectively. This supplement also acts as a potent antioxidant and anti-inflammatory agent, bolstering the immune system and promoting long-term health.

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  • Nicotinamide Adenine Dinucleotide (NAD+) Role in Healthy Aging and Disease Prevention
    Gisela Jimenez Duran

    Nicotinamide Adenine Dinucleotide (NAD+) Role in Healthy Aging and Disease Prevention

    Critical findings on NAD+  NAD+ is an essential molecule for life that primarily acts as a “coenzyme”: a cofactor for enzymes in oxidation-reduction (redox) reactions, facilitating the transfer of hydrogen atoms. This transfer is crucial in enabling cells to adapt to changes such as DNA damage, daily rhythm disruptions, infections, inflammation, exposure to foreign chemicals and one of the most important: nutrient availability and the production of ATP, the cell's main energy currency, essential for proper functioning of all cells in the body.   Interestingly, NAD+ has been identified as a key link connecting oxidative stress, inflammation, caloric restriction, exercise, DNA repair, longevity, and overall health span (1). Maintaining optimal NAD+ levels is thus vital for supporting metabolic health. This is highly relevant in modern societies, where lifestyle factors such as poor dietary habits, chronic stress, sedentarism, lack of sunlight or high exposure to chemicals contribute to an increasing prevalence of impaired metabolic health (2, 3).   Metabolic dysfunction is a root cause of chronic inflammation, which over time can lead to the development of autoimmune diseases—conditions that are increasing at an alarming rate each year (4, 5).    Why is NAD+ considered a hallmark of aging?  Although NAD+ research is dated since the early 1900s, NAD+ has gained a lot of interest in the recent years as it has been identified as a hallmark of aging.   NAD+ levels consistently decline with age due to decreased NAD+ synthesis and increased consumption, driven by NAD+’s increasing demand in essential cellular oxidation-reduction reactions (6). Importantly, NAD+ levels have also been shown to be decreased through overnutrition, alcohol consumption, viral infection and a sedentary lifestyle in clinical and preclinical studies (6,7). Decreased NAD+ levels lead to metabolic alterations and increased disease susceptibility, such as cardiovascular disease, neurodegenerative diseases, and cancer.  Interestingly, studies showed that restoring NAD+ levels in old or diseased animals promoted health and extended lifespan (1). The discovery of NAD+’s crucial role in aging and metabolic health has prompted further research in humans and uncovered its therapeutic potential, driving the growth of a substantial market for NAD-boosting molecules, which have clinically shown promising results in slowing down age-related processes and increasing the body’s resilience to many autoimmune diseases such as Parkinson’s or multiple sclerosis, thereby extending healthy human lifespan (6).    What are NAD+’s main functions in the body?  NAD+ acts in many critical processes in our body (6, 8, 9), including:  Cellular energy production: NAD+ collects hydrogen atoms during glycolysis (breakdown of sugar), fatty acid breakdown, and the subsequent tricarboxylic acid (TCA) cycle - occurring in the mitochondria – which forms NADH. NADH then donates these hydrogens to produce ATP (the cell's main energy currency) through mitochondrial oxidative phosphorylation (OXPHOS). Additionally, NAD+ supports mitochondrial biogenesis, the process of forming new mitochondria, which is critical for energy production and metabolism.  Sirtuin activity and 24-hour daily rhythm cycle (circadian rhythm): NAD+ plays a crucial role in regulating the body's circadian rhythm by directly affecting the transcription of clock genes via enzymes, such as sirtuins (SIRT1/6). Sirtuins act as intracellular NAD+ sensors and have been described to help modulate the circadian clock, influencing metabolism, sleep, and overall health.    DNA repair: NAD+ is essential for activating enzymes known as PARPs (poly(ADP-ribose) polymerases), which are involved in repairing damaged DNA. This function helps maintain genomic stability and prevents the accumulation of DNA damage that contributes to aging and disease development.    How is NAD+ synthesised and regulated?  NAD+ is one of the most common metabolites in the human body and it is in a homeostatic status of biosynthesis, consumption, recycling and degradation at both cellular and systemic levels (Figure 1) (6).   (In agreed, similar figure with information below pending to be generated)  Figure 1. Mammalian cells can synthesize NAD+ de novo from tryptophan by the kynurenine pathway or from NA by the Preiss‐Handler pathway, while most NAD+ is recycled via salvage pathways from nicotinamide (NAM), NA, NR and NMN to maintain the cellular NAD+ levels. NAD+ can be reduced into NADH in the metabolic processes, including glycolysis, fatty acid oxidation and the TCA cycle.  As a co-substrate important to various post-synthesis modifications of fundamental macromolecules, NAD+ can be cleaved (“degraded”) by NAD+-consuming enzymes including: PARPs, sirtuins, CD38 and SARM1, to generate NAM and ADP-ribose. The precursor NR is imported by ENTs and transformed to NMN by NRK (6).    Non-pharmacologic strategies to increase NAD+ bioavailability  Intracellular NAD+ levels can be increased naturally by adopting a series of lifestyle habits, which serve as effective preventive measures to slow the aging process. Thus far, research has shown that NAD+ can be increased by energy stress, including caloric and glucose restriction, as well as exercise (6, 10).   Caloric restriction: Caloric restriction has been shown to help counteract age-related declines in circadian rhythm – the body’s 24-hour cycle – by improving circadian control of NAD+ metabolism and enhancing NAD+/SIRT1-related epigenetic changes. Both long-term and short-term caloric restriction have been shown to reduce artery stiffness and improve endothelial function. Additionally, another study reported that caloric restriction raised NAD+ levels and protected the brain against aging and disease by reducing oxidative stress and cellular damage.    Exercise: Exercise has gained attention for its ability to potentially boost NAD+ levels and SIRT1 activity, by increasing NAMPT. Regular training significantly raises NAMPT protein in the muscles as a way to respond to energy stress, as seen in a study with non-obese sedentary adults.  Boosting NAD+ as a Therapeutic Strategy  NAD+ depletion is a key feature of aging and age-related disorders. Increasing NAD+ levels can slow aging and combat diseases, promoting a longer, healthier life. Therapeutically, NAD+ can be boosted through dietary supplementation of NAD+ precursors such as Trp, NA, NMN and NR, or by inhibition NAD+-consuming enzymes (e.g., PARP1, CD38) (6).  NAD+ precursors, especially the soluble and orally bioavailable molecules NR, NAM, and Niacin, have shown therapeutic potential in human clinical trials. In particular, NR has become one of the most popular options given the high amount of beneficial clinical results in many different NAD+ related diseases (see our article about NR for more detail).  MNM has also been shown to be rapidly absorbed and converted to NAD+ in organs like muscle, liver, and kidney, but its cellular transport mechanisms remain unclear. In addition, MNM has significantly less clinical studies than NR and the other NAD+ precursors and has shown some risks. A study showed that NMN-induced inflammation promoted the development of pancreatic cancer, highlighting the need for long-term safety studies of NMN NAD+ boosters (6, 11, 12).    Conclusions  NAD+ levels regulate many critical processes, including cellular energy balance, genomic stability, metabolism, stress responses, circadian rhythm, inflammation, redox homeostasis and mitochondrial balance. NAD+ levels consistently decline with age, as well as through modern lifestyle poor habits such as overnutrition, alcohol consumption, viral infection and a sedentary lifestyle. Decreased NAD+ levels lead to metabolic alterations and increased prevalence of chronic inflammation leading to autoimmune diseases.   Boosting NAD+ through lifestyle changes such as exercise or caloric restriction can offer a non-pharmacological way to promote healthy aging by improving resilience and extending healthy lifespan. Clinically approved NAD+ pharmacological boosters, NR being the most studied, are uncovering a broad spectrum of health benefits in both healthy and diseased humans, particularly in NAD+ deficiency related pathologies such as aging-related neurodegenerative disorders, cancer, metabolic diseases, acute injury, infection and overall aging.

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  • Nicotinamide Riboside
    Gisela Jimenez Duran

    What is Nicotinamide Riboside?

    Nicotinamide riboside (NR) is a safe and effective way to boost NAD+ levels, which is a key factor in anti-aging. NAD+ levels decline naturally with age, and this decline is linked to a number of age-related diseases.

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I have a sensitive gut and a history of digestive issues, so I am careful about what I put into my body. Since using Nullure's Vitamin D3 + K2, Saffron and Skin Collagen, I've noticed real improvements — better gut health, a calmer nervous system, improved sleep, more energy and fewer hormonal PMS symptoms.

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