Pain Management
Product Details
Formulated by experts, built on scientific research, and made without additives.
Every Nullure product uses ingredients sourced from trusted partners, is third-party tested in Germany for purity and carefully manufactured in small batches in Spain funder strict EU GMP standards.
Allergy Management
Muscle Strength and Hyperthrophy
Immune Enhancement
Brain Function
Reference link
1. Lang-Illievich K, Klivinyi C, Lasser C, Brenna C, Szilagyi I, Bornemann-Cimenti H. Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients. 2023 Mar; 16(6): 1350.
2. Artikoglu B, Beyer C, Zuloff-Shani A, Brener E, Bloch M. Efficacy of Palmitoylethanolamide for Pain: A Meta-Analysis. Pain Phys. 2017 Jul; 20(5): 353-362.
3. Di Nardo G, Bernardo L, Cremon C, Barbara G, Felici E, Evangelisti M, et al. Palmitoylethanolamide and polydatin in pediatric irritable bowel syndrome: A multicentric randomized controlled trial. Nutrition. 2024 Jun; 122: 112397.
4. Cremon C, Stanghellini V, et al. Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome. Aliment Pharmacol Ther. 2017 Apr; 45(7): 909-922.
5. Briskey D, Skinner R, Smith C, Rao A. Effectiveness of PE (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy Participants-A Double-Blind Randomised Controlled Study. Pharmaceuticals (Basel). 2024 Jan; 17(2): 145.
6. Pickering E, Steels E, Steadman K, Rao A, Vitetta L. A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain. Inflammopharmacology. 2022 Dec; 30(6): 2063-2077.
7. Cruccu G, Di Stefano G, Marchettini P, Truini A. Micronized Palmitoylethanolamide: A Post Hoc Analysis of a Controlled Study in Patients with Low Back Pain – Sciatica. CNS Neurol Disord Drug Targets. 2019 Aug; 18(6): 491-495.
8. Steels E, Vankatesh R, Steels E, Vitetta G, Vitetta L. A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis. Inflammopharmacology. 2019 Jun; 27(3): 475-485.
9. Shekhar A, Srivastava A, Verma N, Verma A, Chaturvedi T. The Comparative Efficacy of Palmitoylethanolamide (PEA) With the Combination of Pregabalin and Nortriptyline on Post-extraction Trigeminal Neuropathy by Using Magnetic Resonance (MR) Neurography: A Randomized Clinical Trial. Cureus. 2024 Feb; 16(2): e54843.
10. Briskey D, Ebelt P, Rao A. The Effect of Levagen+ (Palmitoylethanolamide) Supplementation on Symptoms of Allergic Rhinitis—A Double-Blind Placebo-Controlled Trial. Nutrients. 2023 Nov; 15(23): 4940.
11. Kim N, Parolin B, Renshaw D, Deb S, Zariwala M. Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial. Nutrients. 2024 Feb; 16(4): 489.
12. Huschtscha Z, Silver J, Gerhardy M, Urwin C, Kenney N, Le V, et al. The Effect of Palmitoylethanolamide (PEA) on Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training in Healthy Active Adults: A Double-Blind Randomized Control Trial. Sports Med Open. 2024 Jun; 10: 66.
13. Fessler S, Liu L, Chang Y, Yip T, Johnston C. Palmitoylethanolamide Reduces Proinflammatory Markers in Unvaccinated Adults Recently Diagnosed with COVID-19: A Randomized Controlled Trial. J Nutr. 2022 Oct; 152(10): 2218-2226.
14. Rao A, Skinner R, Briskey D. The Efficacy of Palmitoylethanolamide (Levagen+) on the Incidence and Symptoms of Upper Respiratory Tract Infection-A Double Blind, Randomised, Placebo-Controlled Trial. Nutrients. 2023 Oct; 15(20): 4453.
Ingredients You Can Trust
Every formula is built on ingredients backed by human clinical studies, dosed at effective levels, and chosen for bioavailability — how well your body absorbs and uses them. Each ingredient is rigorously vetted and sourced from trusted partners who standardize and batch-test for potency, ensuring quality and real, consistent results.
The NULLURE Safety Standard
We Test for 60+ Markers of Purity
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The formulas our customers come back to, month after month. Developed in-house by nutrition experts, dosed for real results, and tested beyond industry standards. Rooted in research, confirmed by the people who take them every day.
The Nullure Journal
We write about health and wellness the way we formulate — starting from the research. Every article is written by qualified experts in nutrition, health, and human performance and based on peer-reviewed science. If you're curious about nutrition, supplements, and how your body works, the Nullure Journal might be just the thing for you.
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Nicotinamide riboside (NR) is a safe and effective way to boost NAD+ levels, which is a key factor in anti-aging. NAD+ levels decline naturally with age, and this decline is linked to a number of age-related diseases.
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