Safran (Affron®)

1. Jackson P, Forster J, Khan J, Pouchieu C, Dubreuil S, Kennedy D et al. Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults

2. Hausenblas H, Saha D, Dubyak P, Anton S. Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. J Integr Med. 2013 Nov; 11(6): 377-383

3. Mazidi M, Shemshian M, Mousavi S, Norouzy A, Kermani T, Ferns G et al. A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. J Complement Integr Med. 2016 Jun; 13(2): 195-199.

4. Kell G, Rao A, Beccaria G, Clayton P, Inarejos-García A, Prodanov M. affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind

5. Lopresti A, Drummond P, Inarejos-García, Prodanov M. affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. J Affect Disord. 2108 May; 232: 349-357.

6. Lopresti A, Smith S, Metse A, Drummond P. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. J Clin Sleep Med. 2020 Jun; 16(6): 937-947.

7. Nishide A, Fujita T, Nagaregawa Y, Shoyama Y, Ohnuki K, Ohnuki K, et al. Sleep enhancement by saffron extract in randomized control trial. JPT. 2018; 46(8): 1407-1415.

8. Lopresti A, Smith S, Drummond P. An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study.

9. Jang S, Kim D, Choi M. Effects and treatment methods of acupuncture and herbal medicine for premenstrual syndrome/premenstrual dysphoric disorder: systematic review. BMC Complement Altern Med. 2014 Jan; 14: 11.

10. Lopresti A, Smith S. The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study. J Menopausal Med. 2021 Aug; 27(2): 66-78.

11. Lu C, Ke L, Li J, Zhao H, Lu T, Yang K, et al. Saffron (Crocus sativus L.) and health outcomes: a meta-research review of meta-analyses and an evidence mapping study. Phytomed. 2021 Oct; 91: 153699.

12. Midaoui A, Ghzaiel I, Vervandier-Fasseur D, Ksila M, Zarrouk A, Lizard G, et al. Saffron (Crocus sativus L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases. Nutrients. 2022 Feb; 14(3): 597.

13. Liu J, Yang Y, Qu Y. Effect of saffron supplementation on the glycemic outcomes in diabetes: a systematic review and meta-analysis. Front Nutr. 2024 Mar; 11.

14. Ayati Z, Yang G, Ayati M, Emami S, Chang D. Saffron for mild cognitive impairment and dementia: a systematic review and meta-analysis of randomised clinical trials. BMC Complement Med Ther. 2020Nov; 20(1): 333.